Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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6,091 – 6,105 of 60,541 results

6,091

Medchemexpress LLC 1-((2-(2,4-difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate | 86386-77-8 | MFCD13184268 | 50g

1-((2-(2 4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1 2 4-triazole methanesulfonate (Efinaconazole Impurity) is a biological molecule

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6,092

Medchemexpress LLC Er-464195-01 | 859218-37-4 | 99.7% | 379.02 g/mol | C23H39ClN2 | 10MG

ER-464195-01 is an orally active small-molecule inhibitor that disrupts calreticulin binding to integrin α subunits and is provided as a high-purity solid for preclinical in vitro and in vivo research. The compound is DMSO-soluble and has defined storage recommendations for both powder and solution forms.

Inhibits calreticulin-integrin α subunit interaction.
High purity: 99.7%.
Chemical formula: C23H39ClN2.
Molecular weight: 379.02 g/mol.
Appearance: white to off-white solid.
Solubility: soluble in DMSO (≈5 mg/mL) with ultrasonic warming.
Storage: powder at -20°C (long term) or 4°C; solutions at -80°C or -20°C.

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6,093

Medchemexpress LLC HY-125232 5mg Medchemexpress, MS645 CAS:2250091-96-2 Purity:>98%

Medchemexpress, HY-125232 5mg MS645 CAS:2250091-96-2 MS645 is a bivalent BET bromodomains (BrD) inhibitor with a Ki of 18.4 nM for BRD4-BD1/BD2. MS645 spatially constrains bivalent inhibition of BRD4 BrDs resulting in a sustained repression of BRD4 transcriptional activity in solid-tumor cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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6,094

Medchemexpress LLC HY-135653 5mg Medchemexpress, EC5026 CAS:1809885-32-2 Purity:>98%

Medchemexpress, HY-135653 5mg EC5026 CAS:1809885-32-2 EC5026 (BPN-19186) is a first-in-class, potent and orally active soluble Epoxide Hydrolase (sEH) inhibitor. Inhibition of sEH treats pain by stabilizing natural analgesic and anti-inflammatory mediators. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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6,095

Apexbio Technology LLC MK-2461 917879-39-1 10mM (in 1mL DMSO)

MK-2461 (CAS 917879-39-1) is a small molecule inhibitor targeting multiple receptor tyrosine kinases including c-Met (HGFR) Flt1 Flt3 Ron PDGFR and Mer with reported IC50 values of 2 5 nM 10 nM 22 nM 7 nM and 24 nM respectively c-Met frequently overexpressed or mutated in various cancers regulates cell proliferation survival migration invasion and angiogenesis In vitro MK-2461 inhibits hepatocyte growth factor (HGF)/c-Met-dependent mitogenesis cell migration scattering and tubulogenesis In mouse xenograft models of c-Met-driven tumors oral administration of MK-2461 significantly suppresses c-Met signaling and tumor growth MK-2461 is used in oncology research to investigate pathways and therapeutic strategies involving aberrant c-Met signaling

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6,096

Medchemexpress LLC Chordin-like 1/CHRDL 20ug | 20ug

The CHRDL1 protein acts as a BMP4 antagonist blocking its receptor interaction and redirecting neural stem cells from gliogenesis to neurogenesis The role of CHRDL1 in preventing glial cell fate adoption supports neuronal differentiation in the brain Chordin-like 1/CHRDL1 Protein Human (His solution) is the recombinant human-derived Chordin-like 1/CHRDL1 protein expressed by E coli with N-His labeled tag

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6,097

Medchemexpress LLC Valiglurax | 1976050-09-5 | ≥98.0% | 25 MG

Valiglurax is a potent, orally active, and selective positive allosteric modulator of the metabotropic glutamate receptor mGlu4 (VU0652957). It is CNS-penetrant and intended for preclinical research applications such as Parkinson's disease models.

Potent mGlu4 positive allosteric modulator with low-nanomolar activity.
Orally active and central nervous system penetrant.
Solid, light yellow to yellow, suitable for research use.
Molecular formula C16H10F3N5; molecular weight 329.28 g/mol.
Storage: 4°C, protect from light; in solvent: -80°C (6 months), -20°C (1 month).

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6,098

TARGETMOL CHEMICALS INC BELINOSTAT 50MG

Also available in 10 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Belinostat (PXD101) is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC IC50 of 27 nM in HeLa cell extracts)and with antineoplastic activity. purity: 100%

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6,099

Cayman Chemical TCS 401, Purity: ≥95%, CAS: 243966-09-8, 25 mg

A selective inhibitor of PTP1B (Ki = 0.29 µM)

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6,100

Cayman Chemical Fz25, Purity: ≥98%, CAS: 2762498-70-2, 50 mg

A triazole-modified sterol and an anticancer agent; inhibits the proliferation of A2780 and HT-29 cells (IC50s = 15.29 and 15.98 µM, respectively); decreases the phosphorylation of EGFR and STAT3 in A2780 cells at 30.58 µM and phosphorylation of ERK, STAT3, and mTOR in HT-29 cells at 31.96 µM; reduces P-gp efflux activity in a reporter assay using HEK293 cells at 10 µM

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6,101

Medchemexpress LLC GSK8612 | 2361659-62-1 | 99.56% | 520.33 | 50 MG

GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1. It is for research use only and not sold to patients.

Highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor.
Inhibits toll-like receptor (TLR)3-induced IRF3 phosphorylation in Ramos cells.
Inhibits type I IFN secretion in primary human mononuclear cells.
Inhibits secretion of IFNβ in response to dsDNA and cGAMP in THP1 cells.

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6,102

Medchemexpress LLC 4-hydroxybenzaldehyde | 123-08-0 | MFCD00006939 | 100.0% | 122.12 | C7H6O2 | 10g

p-Hydroxybenzaldehyde is a one of the major components in vanilla aroma with antagonistic effect on GABAA receptor of the 1 2 2S subtype at high concentrations

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6,103

Apexbio Technology LLC Parthenolide, 50mg. Cas: 20554-84-1 MFCD: MFCD00134592.

Parthenolide is a sesquiterpene lactone and active principle of feverfew (Chrysanthemum parthenium). Other sizes are available. Please inqury us for quote.

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6,104

Cayman Chemical SU 4942, Purity: ≥98%, CAS: 76086-99-2, 500 mg

A modulator of tyrosine kinase signaling; inhibits VEGF- or acidic FGF-induced mitogenesis of endothelial cells in vitro

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6,105

Cayman Chemical NVP-BAG956, Purity: ≥98%, CAS: 853910-02-8, 5 mg

A dual PDK1 and class I PI3K inhibitor (IC50s = 245, 56, 446, 35, and 117 nM for PDK1, p110α, p110β, p110δ, and p110γ, respectively); inhibits phosphorylation of T308-PKB (IC50 = 45 nM) in and proliferation of U87MG cells (EC50 = 143 nM); induces cell cycle arrest at the G1 phase in MOLM-14 cells and reduces colony formation by patient-derived AML cells; reduces tumor burden in mice injected with 32D.p210-luc+cells when administered in combination with everolimus

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Medchemexpress LLC 1-((2-(2,4-difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate | 86386-77-8 | MFCD13184268 | 50g Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Er-464195-01 | 859218-37-4 | 99.7% | 379.02 g/mol | C23H39ClN2 | 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-125232 5mg Medchemexpress, MS645 CAS:2250091-96-2 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-135653 5mg Medchemexpress, EC5026 CAS:1809885-32-2 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Chordin-like 1/CHRDL 20ug | 20ug Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Valiglurax | 1976050-09-5 | ≥98.0% | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC GSK8612 | 2361659-62-1 | 99.56% | 520.33 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 4-hydroxybenzaldehyde | 123-08-0 | MFCD00006939 | 100.0% | 122.12 | C7H6O2 | 10g Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More